Thesis Project Form
Title (tentative): Characterization of Drusen in patients with dry age-related macular degeneration (AMD) by Color Fundus Photography (CFP) and Spectral Domain Optic Coherence Tomography (SD-OCT)| Thesis advisor(s): Sabatini Silvio P., Nuno Miguel de Pinto Lobo e Matela (Universidade de Lisboa) | E-mail: |
| Address: Via All'Opera Pia, 13 - 16145 Genova (III piano) | Phone: (+39) 010 33 52092 |
Description
Motivation and application domain
his MSc project is integrated in a prospective clinical study that will take place
at Hospital dos Capuchos, Centro Hospitalar Lisboa Central.
at Hospital dos Capuchos, Centro Hospitalar Lisboa Central.
General objectives and main activities
This thesis will be integrated in a prospective clinical study that will take place
at Hospital dos Capuchos, Centro Hospitalar Lisboa Central. The aim of this
study is to establish correlations between drusen type and morphology, evaluated
by Color Fundus Photography (CFP) and Spectral Domain Optic Coherence
Tomography (SD-OCT), with the corresponding Fundus Autofluorescence
(FAF) and Optic Coherence Tomography Angiography (OCT-A) features of the
same drusen in patients with dry age-related macular degeneration (AMD).
The student will start by doing a review of the state-of-the-art in image analysis
in AMD.
The student will have regular meetings with the clinical partners to discuss the
relevance of the imaging biomarkers.
The student will use a previously implemented graphics user interface to analyse
the images and develop new image processing and analysis methods to retrieve
relevant data from the images acquired with the techniques used in the study
(described above).
By the end of this project we will be able to deploy a software that can allow a
quantitative evaluation of disease progression in patients with AMD.
at Hospital dos Capuchos, Centro Hospitalar Lisboa Central. The aim of this
study is to establish correlations between drusen type and morphology, evaluated
by Color Fundus Photography (CFP) and Spectral Domain Optic Coherence
Tomography (SD-OCT), with the corresponding Fundus Autofluorescence
(FAF) and Optic Coherence Tomography Angiography (OCT-A) features of the
same drusen in patients with dry age-related macular degeneration (AMD).
The student will start by doing a review of the state-of-the-art in image analysis
in AMD.
The student will have regular meetings with the clinical partners to discuss the
relevance of the imaging biomarkers.
The student will use a previously implemented graphics user interface to analyse
the images and develop new image processing and analysis methods to retrieve
relevant data from the images acquired with the techniques used in the study
(described above).
By the end of this project we will be able to deploy a software that can allow a
quantitative evaluation of disease progression in patients with AMD.
Training Objectives (technical/analytical tools, experimental methodologies)
The student will develop skills related with image processing, image analysis,
programming in Matlab, physiology of age-related macular degeneration and
biostatistics.
programming in Matlab, physiology of age-related macular degeneration and
biostatistics.
Place(s) where the thesis work will be carried out: Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências da Universidade de Lisboa
Additional information
Maximum number of students: 1
Financial support/scholarship: ERASMUS+