Thesis Project Form
Title (tentative): Characterization of the connections in complex 3D neuronal structures| Thesis advisor(s): Massobrio Paolo, Martina Brofiga | E-mail: |
| Address: Via All'Opera Pia, 13 - 16145 Genova | Phone: (+39) 010 33 52761 |
Description
Motivation and application domain
In vitro models of the brain based on 3D structures, realistic connectivity as well as neuronal compositions are nowadays essential. For this reasons, goal of this thesis is to provide a new experimental model to characterize their functional connections in a precise way and promote a focused chemical stimulation without using microfluidics set-up.
General objectives and main activities
Development of a new experimental protocol to evaluate the connectivity in complex neuronal structures based on cortical and hippocampal neurons.
Training Objectives (technical/analytical tools, experimental methodologies)
Cell culture procedures; Microscopy techniques; MEA-based set-up; Data analysis algorithms, neuronal imaging analysis
Place(s) where the thesis work will be carried out: DIBRIS
Additional information
Pre-requisite abilities/skills: Neuroengineeering, Electrophysiology, MEA, Computational Neuroscience
Curriculum: Neuroengineering
Maximum number of students: 1