Thesis Project Form
Title (tentative): Monitoring Electrospun Small Diameter Vascular Prosthesis with Iron Oxide Nanoparticles| Thesis advisor(s): Pastorino Laura, Pierfrancesco Ferrari | E-mail: |
| Address: Via Opera Pia 13 | Phone: (+39) 010 33 56547 |
Description
Motivation and application domain
This thesis project focuses on fabricating a small
diameter ( 5 mm) vascular
prosthesis using electrospinning technology. The scaffold is engineered from
a blend of polycaprolactone (PCL) and poly(glycerol sebacate) (PGS),
integrated with iron oxide nanoparticles for MRI traceability and quercetin to
improve bioactivity and antioxidant effects. This aims to enhance graft
diameter ( 5 mm) vascular
prosthesis using electrospinning technology. The scaffold is engineered from
a blend of polycaprolactone (PCL) and poly(glycerol sebacate) (PGS),
integrated with iron oxide nanoparticles for MRI traceability and quercetin to
improve bioactivity and antioxidant effects. This aims to enhance graft
General objectives and main activities
The main objective of this proposal is the fabrication and characterization of a vascular prosthesis produced via electrospinning, engineered with iron oxide nanoparticles for MRI monitoring and quercetin for its anti-inflammatory properties. The experimental work will focus on the electrospinning of a blend of two biomedical-grade polymers combined with iron oxide nanoparticles, the synthesis of the nanoparticles themselves, and a comprehensive set of characterization techniques. These will include scanning and transmission electron microscopy, FT-IR spectroscopy, X-ray diffraction, vibrating sample magnetometry (VSM), dynamic mechanical analysis, and in vitro testing.
Training Objectives (technical/analytical tools, experimental methodologies)
To gain practical experience in biofabrication and characterization of biongnieered scaffolds.
Place(s) where the thesis work will be carried out: DIBRIS and DICCA
Additional information
Maximum number of students: 1