Thesis Project Form
Title (tentative): Study of the role of natural and synthetic compounds on 3D cancer models aggressiveness and their in vitro progression| Thesis advisor(s): Fato Marco Massimo, Sivlia Scaglione - Alessandra Marrella | E-mail: |
| Address: Via All'Opera Pia, 13 - 16145 Genova | Phone: (+39) 010 33 52789 |
Description
Motivation and application domain
Three-dimensional (3D) cell cultures are necessary tools in the progression of cancer research. These can be adopted as in vitro predictive models to study the effectiveness of pharmacological or natural treatments.
General objectives and main activities
The goal is to develop 3D cell-laden hydrogels as tumor models and in vitro analyze cancer cells response to natural or synthetic compounds, both in static and dynamic conditions.
The student will participate to the process of hydrogel manufacturing and cells culture. The work will be constituted by a major experimental part (hydrogel processing, optical microscopy, fluorescence confocal microscopy, CFD) and consequent images post-production and data analysis.
The student will participate to the process of hydrogel manufacturing and cells culture. The work will be constituted by a major experimental part (hydrogel processing, optical microscopy, fluorescence confocal microscopy, CFD) and consequent images post-production and data analysis.
Training Objectives (technical/analytical tools, experimental methodologies)
• Optical microscopy
• Fluorescence confocal microscopy
• Hydrogel processing
• Cell culture
• Image analysis
• CFD
• Fluorescence confocal microscopy
• Hydrogel processing
• Cell culture
• Image analysis
• CFD
Place(s) where the thesis work will be carried out: CNR – Consiglio Nazionale delle Ricerche, istituto IEIIT, UNIGE - DIBRIS
Additional information
Pre-requisite abilities/skills: Self-contained, interest in experimental work; initiative and curiosity.
Maximum number of students: 1