Thesis Project Form
Title (tentative): Characterization of the functional and dynamical properties of cortical-hippocampal networks coupled to Micro-Electrode Arrays| Thesis advisor(s): Massobrio Paolo, Martina Brofiga | E-mail: |
| Address: Via All'Opera Pia, 13 - 16145 Genova | Phone: (+39) 010 33 52761 |
Description
Motivation and application domain
In this project, the candidate will investigate the functional and dynamical properties of the cortical-hippocampal system during its development from 11 to 25 days in vitro (DIV) by means of a novel polymeric device coupled to Micro-Electrode Arrays (MEAs) to realize interconnected regions of dissociated cortical and hippocampal neurons.
General objectives and main activities
Development of ad hoc algorithms to investigate the functional and dynamical properties of the cortical-hippocampal system during its development from 11 to 25 days in vitro (DIV).
Bursting propagation and functional connectivity estimation are the topics will be explored during this computational work
Bursting propagation and functional connectivity estimation are the topics will be explored during this computational work
Training Objectives (technical/analytical tools, experimental methodologies)
- Functional connectivity algorithm
- Thresholding procedures
- Estimation of the topological properties of a network
- Thresholding procedures
- Estimation of the topological properties of a network
Place(s) where the thesis work will be carried out:
Additional information
Pre-requisite abilities/skills: Computational Neuroscience, Matlab Programming
Curriculum: Neuroengineering
Maximum number of students: 1