Thesis Project Form
Title (tentative): Characterisation of ihPSC derived neuronal networks on MEA HD: physiological and pathological conditions| Thesis advisor(s): Martinoia Sergio, Lorenzo Muzzi | E-mail: |
| Address: | Phone: (+39) 010 33 52980 |
Description
Motivation and application domain
Data acquisition using 3Brain Duplex systems and Accura HD-MEA
Data processing and analysis using MATLAB
Data processing and analysis using MATLAB
General objectives and main activities
The aim of this thesis is to adapt an algorithm that allows us to trace the action potential of neurons on HD-MEA in an automated way and that allows us to extract parameters to characterize its propagation. This will be used to evaluate the propagation properties of neuronal cultures derived from different patients. The student will have available electrophysiological data deriving from neuronal cultures derived from patients recorded on MEA-HD.
Training Objectives (technical/analytical tools, experimental methodologies)
Data acquisition using 3Brain Duplex systems and Accura HD-MEA
Data processing and analysis using MATLAB
Data processing and analysis using MATLAB
Place(s) where the thesis work will be carried out: Gaslini Hospital
Additional information
Maximum number of students: 1