Thesis Project Form
Title (tentative): Developing closed-loop electrical stimulation to investigate learning and memory mechanism in human derived neuronal network on MEA-HD| Thesis advisor(s): Martinoia Sergio, Lorenzo Muzzi | E-mail: |
| Address: | Phone: (+39) 010 33 52980 |
Description
Motivation and application domain
Programming python/matlab/c++
Data acquisition, processing and analysis
Neuronal culture maintainance
Data acquisition, processing and analysis
Neuronal culture maintainance
General objectives and main activities
The aim of this thesis will be to develop a closed-loop stimulation on the 3Brain Ag Biocam DupleX recording system. The student will have an API available to be able to implement the closed loop stimulation on the recording system and will have to interface with the 3Brain company. The program must be able to stimulate freely from pairs of independent electrodes and with variable current stimuli. It must be able to recalibrate the stimulation parameters in real time based on the network responses obtained in real time, minimizing the latency between the computer and the recording system. Once implemented, the student will have to test the effect of different closed-circuit stimulations on ad hoc prepared biological samples.
Training Objectives (technical/analytical tools, experimental methodologies)
Programming python/matlab/c++
Data acquisition, processing and analysis
Neuronal culture maintainance
Data acquisition, processing and analysis
Neuronal culture maintainance
Place(s) where the thesis work will be carried out: Gaslini Hospital
Additional information
Maximum number of students: 1